421. in debt 欠债，欠情
He is probably up to his neck in debt.
422. in demand 非常需要的，受欢迎的
Food is being in demand in the poor village.
He was much in demand as a lecturer in the US.
423. in detail 详细地
He thought it out in detail.
424. in difficulty 处境困难
We should help the friends in difficulty.
425. in effect 实际上，事实上；有效
This will, in effect, make your television a computer.
That policy would also be in effect for two years.
426. in fact其实，实际上
In fact, those people have been promoted.
427. in favour of 支持，赞成
Some are in favour of it, some are against it.
428. in front of 面对，在...前
We dried our clothes in front of the fire.
He was robbing this old lady right in front of us.
429. in general 一般来说，大体上
We talked about love in general.
In general they play a very positive role.
430.in hand 在进行中，待办理
The task his boss assigned is in hand.
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